PE-22-28 8mg

Buy PE-22-28 8mg here at Biotech Peptides: a TREK-1 blocking peptide in a 8mg vial, sealed and freeze-dried. It’s in stock at $55, with free shipping worldwide on every order. Our label says it plainly: synthesized and lyophilized in the USA. Scroll the product images to see the lot’s certificate of analysis.

PE-22-28 at a glance

PE-22-28 is a seven-amino-acid peptide, Gly-Val-Ser-Trp-Gly-Leu-Arg, shortened from spadin. Spadin comes from the propeptide of sortilin, a protein involved in moving other proteins around inside neurons.

It was developed by Jean Mazella’s group in France as a more stable version of spadin. It’s a research compound only.

What studies report about PE-22-28

Mazella and colleagues described spadin in PLoS Biology in 2010 as a blocker of the TREK-1 potassium channel with antidepressant-like effects in mice.

In 2017, Djillani and colleagues reported shorter analogs, including PE-22-28, that lasted longer and showed similar effects in mouse models within four days.

For the primary literature, PubMed lists the PE-22-28 studies.

PE-22-28 mechanism of action

PE-22-28 blocks TREK-1, a potassium channel that keeps neurons quiet. Mice lacking TREK-1 are resistant to depression-like behavior in standard tests, which is what made the channel a target.

In the mouse studies, blocking it also raised markers of new neuron formation in the hippocampus.

PE-22-28 8mg product details

• Compound: PE-22-28
• Other names: spadin analog
• Sequence or structure: Gly-Val-Ser-Trp-Gly-Leu-Arg
• Amount: 8mg
• Form: lyophilized (freeze-dried) powder
• Made: synthesized and lyophilized in the USA
• Lot paperwork: COA, HPLC and MS images in the gallery
• SKU: PE-22-28-8mg

Lot testing for PE-22-28 8mg

We show the paperwork instead of describing it. Open the gallery and you’ll find the COA with its lot number and test table, an HPLC trace for purity and a mass spec plot for identity.

Want a copy for your records? Contact us with your order number and we’ll send the file.

How to mix PE-22-28 8mg

The concentration is the 8mg in the vial divided by the water you add:

• 1mL of water: 8mg per mL
• 2mL of water: 4mg per mL
• 3mL of water: 2.67mg per mL

Let the vial warm to room temperature first. Run the water slowly down the side of the glass, then swirl or roll it until the powder is gone. Don’t shake it; foam is a sign of damaged peptide.

Dry vials last longest frozen at -20°C. Reconstituted solution goes in the fridge and is best used within four weeks or so.

Planning a study with PE-22-28 8mg

Work out the total amount the protocol needs first, then add about 20% for test runs and the odd lost dose. Ordering everything from one lot keeps the material consistent through the whole study.

Where PE-22-28 fits

PE-22-28 is a short spadin analog that blocks the TREK-1 potassium channel. If you’re choosing between options, these are the usual alternatives:

• Semax is built on a fragment of ACTH and linked to BDNF in rodent studies
• N-Acetyl Semax is Semax with protective groups on both ends so it lasts longer in solution
• Selank is built on tuftsin and studied for anxiety through the GABA system
• N-Acetyl Selank is Selank with protective groups on both ends
• DSIP is a nine-amino-acid peptide first isolated from rabbits in deep sleep

These reach the brain through different systems: BDNF, GABA, sleep regulation and a potassium channel. All of them are on our nootropic peptides page.

Related nootropic peptides

• Selank 10mg, a tuftsin analog
• DSIP 5mg, a neuropeptide
• Pinealon 20mg, a bioregulator peptide
• N-Acetyl Selank 10mg, a capped Selank analog

See everything in nootropic peptides, or browse all research peptides from the Biotech Peptides home page.

PE-22-28 8mg from a store that sells peptides only

We sell research peptides and nothing else, close to 90 of them, so questions about PE-22-28 8mg reach people who handle these products every day. Orders are packed from stock, and every listing shows its real price No membership, no minimum order.

Problems with an order go through the contact page. Include the order number and a photo of anything damaged.

Free shipping on PE-22-28 8mg

Every order ships free, domestic or international. Dry peptide is stable at room temperature for the length of a normal delivery, so there’s no ice pack surcharge. Freeze it once it lands.

Every product is listed in our shop, and the Biotech Peptides Shop home page links to the blog’s country-by-country delivery guides.

PE-22-28 8mg questions and answers

How should PE-22-28 8mg be stored?

Frozen at -20°C while dry. After mixing, in the fridge at 2 to 8°C, used within about four weeks.

Does PE-22-28 8mg come with a COA?

Yes. The certificate of analysis, HPLC trace and mass spectrum for the lot are in the product images.

Is PE-22-28 8mg in stock?

Yes, it’s in stock today.

Where can I buy PE-22-28 8mg?

From this page on biotechpeptidesshop.com, the Biotech Peptides store.

Is PE-22-28 approved for human use?

No. It’s sold for laboratory research only and isn’t for human or veterinary use.

PE-22-28 8mg for sale now

Get PE-22-28 8mg for $55. It’s in stock, shipping is free, and the cart button is right above.

Building a larger order? Browse the nootropic peptides as well.

For laboratory research only. Not for human or veterinary use, and not evaluated by the FDA.