PNC-27 5mg

Buy PNC-27 5mg here at Biotech Peptides: a p53-derived peptide in a 5mg vial, sealed and freeze-dried. It’s in stock at $142, with free shipping worldwide on every order. Our label says it plainly: synthesized and lyophilized in the USA. The gallery above includes the certificate of analysis for the current lot.

About PNC-27

PNC-27 is a 32-amino-acid peptide made of two parts: residues 12 to 26 of the tumor suppressor protein p53, the stretch that binds HDM-2, joined to a membrane-residency sequence called penetratin. It came from Matthew Pincus and colleagues at SUNY Downstate in New York.

It’s a research peptide only. It hasn’t been through clinical trials and isn’t approved for any use.

PNC-27 research so far

Cell culture papers from the Pincus group report that PNC-27 kills a range of cancer cell lines, including pancreatic, breast and leukemia cells, while leaving normal cells such as fibroblasts and stem cells largely intact.

Their explanation is that many cancer cells carry HDM-2 on their outer membrane. Most of the published work comes from that one group, so independent data is limited.

Search the original papers yourself on PubMed.

PNC-27 mechanism of action

The p53 part of PNC-27 binds HDM-2 on the cancer cell’s membrane. Once bound, the peptide forms pores in the membrane and the cell dies by necrosis, which is much faster than programmed cell death (apoptosis).

Normal cells mostly keep HDM-2 inside, so in culture the peptide has much less to bind on them. That selectivity is the main reason PNC-27 is studied.

PNC-27 5mg product details

• Compound: PNC-27
• Other names: p53-penetratin peptide
• Sequence or structure: p53 residues 12-26 linked to penetratin
• Amount: 5mg
• Form: lyophilized (freeze-dried) powder
• Made: synthesized and lyophilized in the USA
• Lot paperwork: COA, HPLC and MS images in the gallery
• SKU: PNC-27-5mg

Lot testing for PNC-27 5mg

We show the paperwork instead of describing it. Open the gallery and you’ll find the COA with its lot number and test table, an HPLC trace for purity and a mass spec plot for identity.

Want a copy for your records? Contact us with your order number and we’ll send the file.

Reconstituting PNC-27 5mg

Divide 5mg by the volume of water and you have the concentration:

• 1mL of water: 5mg per mL
• 2mL of water: 2.5mg per mL
• 3mL of water: 1.67mg per mL

Let the vial warm to room temperature first. Run the water slowly down the side of the glass, then swirl or roll it until the powder is gone. Don’t shake it; foam is a sign of damaged peptide.

Dry vials last longest frozen at -20°C. Reconstituted solution goes in the fridge and is best used within four weeks or so.

Ordering enough PNC-27 5mg

Work out the total amount the protocol needs first, then add about 20% for test runs and the odd lost dose. Ordering everything from one lot keeps the material consistent through the whole study.

PNC-27 compared with similar peptides

In short, PNC-27 is a p53-derived peptide that binds HDM-2 on cancer cell membranes. Here’s how its neighbors differ:

• Thymosin Alpha-1 is a 28-amino-acid thymic peptide, approved in several countries as thymalfasin
• LL-37 is the only human cathelicidin, an antimicrobial peptide that also signals in wound repair
• VIP is a 28-amino-acid neuropeptide that relaxes smooth muscle and calms immune cells
• Thymalin is a thymus peptide complex from the Leningrad bioregulator program

All are immune research tools, but they act at very different points, from T cell maturation to direct antimicrobial action. All of them are on our immune peptides page.

Related immune peptides

• VIP 6mg, a neuropeptide
• Vilon 20mg, a dipeptide bioregulator
• Thymalin 25mg, a thymic peptide complex
• LL-37 5mg, an antimicrobial peptide

See everything in immune peptides, or browse all research peptides from the Biotech Peptides home page.

Buying PNC-27 5mg from Biotech Peptides

We sell research peptides and nothing else, close to 90 of them, so questions about PNC-27 5mg reach people who handle these products every day. Orders are packed from stock, and every listing shows its real price No membership, no minimum order.

Problems with an order go through the contact page. Include the order number and a photo of anything damaged.

Shipping PNC-27 5mg worldwide

Every order ships free, domestic or international. Dry peptide is stable at room temperature for the length of a normal delivery, so there’s no ice pack surcharge. Freeze it once it lands.

Every product is listed in our shop, and the Biotech Peptides Shop home page links to the blog’s country-by-country delivery guides.

PNC-27 5mg questions and answers

Where can I buy PNC-27 5mg?

From this page on biotechpeptidesshop.com, the Biotech Peptides store.

Is PNC-27 approved for human use?

No. It’s sold for laboratory research only and isn’t for human or veterinary use.

How much does shipping cost?

Nothing. Shipping is free on every order worldwide.

What do I reconstitute PNC-27 5mg with?

Sterile bacteriostatic water. The mixing section above lists concentrations for common volumes.

How should PNC-27 5mg be stored?

Frozen at -20°C while dry. After mixing, in the fridge at 2 to 8°C, used within about four weeks.

Order PNC-27 5mg from Biotech Peptides

Get PNC-27 5mg for $142. It’s in stock, shipping is free, and the cart button is right above.

Building a larger order? Browse the immune peptides as well.

For laboratory research only. Not for human or veterinary use, and not evaluated by the FDA.